COMBINATIONS OF WHARTON JELLY DERIVED EXOSOMES AND SALICYLIC ACID: A NEW HOPE FOR ERADICATION OF CUTANEOUS LEISHMANIASIS


Koken G. Y. , ABAMOR E. Ş. , Allahverdiyev A. , Karaoz E.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.31, no.3A, pp.3241-3256, 2022 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3A
  • Publication Date: 2022
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.3241-3256
  • Keywords: Leishmaniasis, extracellular vesicles, exosome, mesenchymal stem cell, Wharton Jelly, salicylic acid, MESENCHYMAL STEM-CELLS, UMBILICAL-CORD, GENE-EXPRESSION, TELOMERASE, ANGIOGENESIS

Abstract

The aim of the current study is to obtain wharton jelly derived exosomes, prepare therapeutic formulations including combinations of isolated exosomes and salicylic acid, investigate their in vitro antileishmanial activities against L.major promastigotes and amastigotes in order to develop a new alternative approach for recovery of Cutaneous Leishmaniasis.