OMURİLİK HASARLARININ TEDAVİSİNDE KULLANILABİLECEK GRAFEN TEMELLİ DOKU İSKELELERİ


Başkapan B., Çelik D., Üstündağ C. B.

8. Uluslararası Bilimsel Araştırmalar Kongresi, Çorum, Türkiye, 22 - 23 Ağustos 2020, ss.107-108

  • Basıldığı Şehir: Çorum
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.107-108

Özet

Spinal cord is connection that provides nerve conduction between brain and rest of body. Spinal cord injuries usually cause interruption of electrochemical circulation due to vertebrae to slip or break into spinal cord and damage the neural cells by sudden traumas such as sports or motor vehicle accidents. This leads to loss of sensory and motor control in entire body below injury site. Current treatment methods for spinal cord injured individuals are aimed at preventing complications rather than functional repair. The recovery rate in this psychologically and economically severe disease is less than 1%. Tissue engineering is the most promising field in the treatment of this disease. A suitable biomaterial can provide appropriate microenvironment for neurogenesis by displaying properties similar to that of native spinal cord. As nervous system shows functions based on electrical activities, graphene is ideal material for neural models.

In this study, a graphene-based tissue scaffold was prepared and characterized. Graphene oxide obtained by chemical exfoliation from graphite, which was used to obtain scaffold with 3D structure by freeze-drying method. Reducing process by thermal and chemical was made to obtain graphene oxide with different carbon/oxygen ratios. Electrical conductivity of graphene oxide ribbon prepared by vacuum filtration technique was measured. Synthesized graphene oxide was characterized by FTIR, AFM, UV spectrophotometer, and SEM-EDS. SEM images of the scaffold showed that scaffold with a three-dimensional and porous structure was obtained. C/O ratio of thermal and chemical reduced graphene oxide was determined 9.52 and 27.93 respectively; and electrical conductivity of it was determined 190.5 and 2831.65 S/m, respectively. Electrical conductivity analysis showed that graphene had a similar conductivity value as spinal cord.