Quantification of Regional Interstitial Lung Disease from CT-derived Fractional Tissue Volume: A Lung Tissue Research Consortium Study

Yilmaz C. , WATHARKAR S. S. , DE LEON A. D. , GARCIA C. K. , PATEL N. C. , JORDAN K. G. , ...Daha Fazla

ACADEMIC RADIOLOGY, cilt.18, sa.8, ss.1014-1023, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Konu: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.acra.2011.03.004
  • Sayfa Sayıları: ss.1014-1023


Rationale and Objectives: Evaluation of chest computed tomography (CT) is usually qualitative or semiquantitative, resulting in subjective descriptions often by different observers over time and imprecise determinations of disease severity within distorted lobes. There is a need for standardized imaging biomarkers to quantify regional disease, maximize diagnostic yield, and facilitate multicenter comparisons. We applied lobe-based voxelwise image analysis to derive regional air (Vair) and tissue (Vtissue) volumes and fractional tissue volume (FTV = tissue/[tissue+air] volume) as internally standardized parameter for assessing interstitial lung disease (ILD).