Quantification of Regional Interstitial Lung Disease from CT-derived Fractional Tissue Volume: A Lung Tissue Research Consortium Study


Yilmaz C. , WATHARKAR S. S. , DE LEON A. D. , GARCIA C. K. , PATEL N. C. , JORDAN K. G. , ...More

ACADEMIC RADIOLOGY, vol.18, no.8, pp.1014-1023, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1016/j.acra.2011.03.004
  • Title of Journal : ACADEMIC RADIOLOGY
  • Page Numbers: pp.1014-1023

Abstract

Rationale and Objectives: Evaluation of chest computed tomography (CT) is usually qualitative or semiquantitative, resulting in subjective descriptions often by different observers over time and imprecise determinations of disease severity within distorted lobes. There is a need for standardized imaging biomarkers to quantify regional disease, maximize diagnostic yield, and facilitate multicenter comparisons. We applied lobe-based voxelwise image analysis to derive regional air (Vair) and tissue (Vtissue) volumes and fractional tissue volume (FTV = tissue/[tissue+air] volume) as internally standardized parameter for assessing interstitial lung disease (ILD).