ULUSLARARASI MARMARA FEN BİLİMLERİ KONGRESİ, Kocaeli, Türkiye, 1 - 03 Kasım 2019, ss.1
Quinazolines are a pharmacologically very attractive class of compounds and have shown activity in various assays. This group of compounds exhibits numerous pharmacological activities such as antimicrobial, antitumoral, anti-inflammatory, antihyperlipidemic, antihypertensive, and anticonvulsant properties1,2. They have an important place in the area of heterocyclic compounds because of their presence in the structures of macrocyclic complex drugs, their applications in industry, and usage in pharmaceutical researches due to their biological properties.
In the current study, some new substituted quinazoline derivatives which are considered that may possess biological activity have been obtained via one-pot multicomponent method by using hetaryl carboxaldehydes, guanidine carbone and cyclohexanone3; (Figure 1) and the structures of all these synthesized compounds have been clarified with spectral data.
This sequential multi-component approach is advantageous as it combines shortened reaction times, minimal workup, and reduced waste production4. All starting materials are commercially available and a broad variety of compounds can be readily synthesized.