Evaluation of paraffin wax and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) blend patch for tissue engineering

Yildirim M. A., Demirbilek M., Türkoğlu N.

MATERIALS TECHNOLOGY, vol.36, no.2, pp.105-117, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1080/10667857.2020.1734722
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, Chimica, Communication Abstracts, Compendex, Computer & Applied Sciences, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.105-117
  • Yıldız Technical University Affiliated: Yes


In the study, we aimed to develop a multipurpose tissue patch for the repairment of various tissue defects. Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was blended with paraffin wax, and the chemical composition of the membranes was determined by the FTIR and RAMAN spectroscopy. The surface area of the PHBHHx and PHBHHx/Paraffin wax were determined as (38,79 m(2)/g) and (81,108 m(2)/g), respectively. The DMA and DSC results revealed that blending with paraffin wax, increased the percentage of elongation of the PHBHHx membrane by 7,6% and reduced the modulus of elasticity. While the elongation at break of PHBHHx tissue patch was 22,463% (standard error = +/- 2,476), addition of Paraffin wax increased the value to 30,038% (standard error = +/- 7,228). The antioxidant capacity significantly increased and p53/TP53 levels decreased after blending with paraffin. In conclusion, PHBHHx/paraffin wax blend patches can be considered as a promising biomaterial due to their high cell adhesion capacity depending on its increased surface area, fine anti-oxidant properties, and appropriate mechanical properties.