Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Buyuk N. I., Arayici P., DERMAN S., Mustafaeva Z., YÜCEL S.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.82, sa.1, ss.131-138, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.36468/pharmaceutical-sciences.630
  • Dergi Adı: INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.131-138
  • Anahtar Kelimeler: Amiodarone, chitosan nanoparticles, cyclodextrin, drug release, ionic gelation method, CYCLODEXTRIN/CHITOSAN NANOPARTICLES, DRUG, ULTRASONICATION, FORMULATION, SYSTEM
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

This work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with beta-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodarone-loaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.