Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Buyuk N. I., Arayici P., DERMAN S., Mustafaeva Z., YÜCEL S.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.82, no.1, pp.131-138, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.36468/pharmaceutical-sciences.630
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, Veterinary Science Database
  • Page Numbers: pp.131-138
  • Keywords: Amiodarone, chitosan nanoparticles, cyclodextrin, drug release, ionic gelation method, CYCLODEXTRIN/CHITOSAN NANOPARTICLES, DRUG, ULTRASONICATION, FORMULATION, SYSTEM
  • Yıldız Technical University Affiliated: Yes


This work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with beta-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodarone-loaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.