Differential Pulse Voltammetric Determination of Serotonin Using an Acid-Activated Multiwalled Carbon Nanotube - Over-Oxidized Poly(3,4-ethylenedioxythiophene) Modified Pencil Graphite Electrode

GÖRDÜK Ö.

ANALYTICAL LETTERS, cilt.53, sa.7, ss.1034-1052, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/00032719.2019.1693583
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1034-1052
  • Anahtar Kelimeler: Differential pulse voltammetry (DPV), electrochemical sensor, human blood serum, multi-walled carbon nanotube, pencil graphite electrode (PGE), poly(3, 4-ethylenedioxythiophene), serotonin, PERFORMANCE LIQUID-CHROMATOGRAPHY, ELECTROCHEMICAL OXIDATION, SENSITIVE DETERMINATION, URIC-ACID, ONE-STEP, DOPAMINE, SENSOR, 5-HT, FILM, NEUROTRANSMITTERS
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

In this study, acid-activated multi-walled carbon nanotubes (AA-MWCNT) and poly(3,4-ethylenedioxythiophene) (PEDOT) were deposited on a pencil graphite electrode (PGE) surface for electrochemical sensing applications. The acid-activated multi-walled carbon nanotube/over-oxidized poly(3,4-ethylenedioxythiophene) modified pencil graphite electrode (AA-MWCNT/OO-PEDOT/PGE) was characterized using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). The sensing properties of the obtained surface were examined for the voltammetric determination of serotonin in a phosphate buffer solution. The effects of the pH, adsorption time, over-oxidation and polymerization parameters on the electrochemical properties of serotonin were investigated. The effects of possible interfering substances were evaluated. The detection limit was determined to be 0.092 mu M based on a signal-to-noise ratio of 3. Analytical applications of AA-MWCNT/OO-PEDOT/PGE were successfully tested for the determination of serotonin in human blood serum samples.