Modification of Polysulfones by Click Chemistry: Amphiphilic Graft Copolymers and Their Protein Adsorption and Cell Adhesion Properties

Yilmaz G., Toiserkani H., Demirkol D. O. , Sakarya S., TİMUR S., Yağcı Y., ...More

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, vol.49, no.1, pp.110-117, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1002/pola.24424
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.110-117


Well-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized and characterized. For this purpose, commercially available PSU was converted to azido-functionalized polymer (PSU-N-3) by successive chloromethylation and azidation processes. Independently, poly(tert-butyl acrylate) (PtBA) with an alkyne-end-group is obtained by using suitable initiator in atom transfer radical polymerization (ATRP). Then, this polymer was successfully grafted onto PSU-N3 by click chemistry to yield polysulfone-graft-poly(tert-butyl acrylate), (PSU-g-PtBA). Finally, amphiphilic polysulfone-graft-poly(acrylic acid), (PSU-g-PAA), membranes were obtained by hydrolyzing precursor the PSU-g-PtBA membranes in trifluoroacetic acid. The final polymer and intermediates at various stages were characterized by H-1 NMR, FTIR, GPC, and SEM analyses. Protein adsorption and eukaryotic and prokaryotic cell adhesion on PSU-g-PAA were studied and compared to those of PSU-g-PtBA and unmodified PSU. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 110 117, 2011