Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis

Simsek Ö., Saris P. E. J.

BIOTECHNOLOGY LETTERS, vol.31, no.3, pp.415-421, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1007/s10529-008-9891-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.415-421
  • Keywords: Cycle changing medium, Feedback inhibition, Lactococcus lactis, Nisin production, SUPPLEMENTED WHEY PERMEATE, CULTURES, BATCH, UL719, AERATION
  • Yıldız Technical University Affiliated: No


High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.