Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis


Simsek Ö. , Saris P. E. J.

BIOTECHNOLOGY LETTERS, vol.31, no.3, pp.415-421, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1007/s10529-008-9891-2
  • Title of Journal : BIOTECHNOLOGY LETTERS
  • Page Numbers: pp.415-421

Abstract

High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.