The effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength

Yurttaş A. G., Sevim A. M., Çınar K., Atmaca G., ERDOĞMUŞ A., Gül A.

Dyes and Pigments, vol.198, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 198
  • Publication Date: 2022
  • Doi Number: 10.1016/j.dyepig.2021.110012
  • Journal Name: Dyes and Pigments
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Phthalocyanine, Photodynamic therapy, Dark cytotoxicity, Light cytotoxicity, Absorbed fluence, Laser fluence, WATER-SOLUBLE PHTHALOCYANINES, PHOTODYNAMIC THERAPY, IN-VITRO, PHOTOPHYSICAL PROPERTIES, ACID, ZINC, NANOPARTICLES, SUBSTITUENTS, MECHANISMS, FEATURES
  • Yıldız Technical University Affiliated: Yes


© 2021 Elsevier LtdPhotodynamic therapy (PDT) is an alternative way to treat the cancer non-surgically with minimum harm, in which a specific light and light sensitive photosensitizer (PS) is used. This study deals with the utilization of zinc photosensitizers (λmax ∼700 nm) from the group of phthalocyanines in photodynamic therapy. The photosensitizers differed in bearing either tetra- or octa-mercaptopropionic acid groups. The phthalocyanines (L1ZnPc and DipZnPc) were tested in cancer cell line, HeLa cell (epitheloid cervix carcinoma), by dark and light cytotoxicity. The photophysico-chemical properties of the resulting zinc photosensitizers were analyzed and to investigate the singlet oxygen's efficiency, photochemical properties were determined. For L1ZnPc, the singlet oxygen quantum yield was ΦΔ = 0.41 and for DipZnPc, the value was ΦΔ = 0.27. In addition to the experimental outcomes, this study handles detailed calculations of the absorbed light dose by the photosensitizer at a specific wavelength. In the light of this study, the researchers could get the insight of the precise amount of energy delivered to the cells by a laser beam for critical applications. The absorbed dose of the laser irradiation was calculated within a true wavelength range that is the most detailed explanation in literature.