Polyacrylic acid and polyacrylic acid sodium salt as ınhibitors of calcium oxalate crystal formation

Al-Dubai A., Akyol E.

Bulgarian Chemical Communications, vol.55, no.3, pp.278-282, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.34049/bcc.55.3.ncntc08
  • Journal Name: Bulgarian Chemical Communications
  • Journal Indexes: Scopus
  • Page Numbers: pp.278-282
  • Keywords: Calcium oxalate, Inhibitors, Polyacrylic acid sodium salt, Scale formation
  • Yıldız Technical University Affiliated: Yes


In both industrial machinery and medical field, calcium oxalate (CaOx) crystal formation is a significant issue. This formation must be minimized to avoid problems and ensure optimal equipment performance in industries. To contribute to the development of preventative measures, this research aimed to examine the inhibitory effects of polyacrylic acid (PAA) and polyacrylic acid sodium salt (PAANa) on CaOx crystal formation. A batch crystallization technique was used to investigate the inhibitory effects of PAA and PAANa on CaOx crystal formation at four different concentrations (0.5, 0.75, 1, and 2 ppm) in aqueous solutions at 37°C. The Langmuir adsorption isotherm was utilized to investigate the adsorption mechanism of the inhibitors.The study found that PAA prevented crystal growth by 50–90%, while PAANa was more effective, reducing it by 95–98%. Additionally, the differential heat of adsorption of Qdiff for the kink Langmuir adsorption isotherm for PAA and PAANa was 41.56 and 49.28 KJ/mol, respectively. The findings demonstrate the potential use of PAA and PAANa as inhibitors and advance our understanding of the fundamental principles underlying CaOx crystal formation. Therefore, this research contributes to the development of preventative measures to avoid these problems, ensure optimal equipment performance in industries and prevent kidney stone formation in the medical field.