The present study examined whether life satisfaction mediated social safeness and psychological vulnerability in Turkish youth. The participants included 261 university students who completed a questionnaire package that included the Turkish versions of the Social Safeness and Pleasure Scale, the Satisfaction with Life Scale, and the Psychological Vulnerability Scale. To test the proposed mediation model, authors employed hierarchical regressions. Furthermore, the authors tested mediation model using the Sobel Z-test and bootstrapping method to examine any indirect effects. Consistent with our hypotheses, the results indicated that there was a positive relationship between social safeness and life satisfaction, and a negative relationship between social safeness and psychological vulnerability. The results of the Sobel Z-test and bootstrapping revealed that life satisfaction significantly, yet partially, mediated the relationship between social safeness and psychological vulnerability. The findings highlight the importance of life satisfaction in enhancing perceptions of social safeness and decreasing psychological vulnerability among Turkish college students.