In the presented work, synthesis of the ternary sodium alginate based hydrogels as drug delivery systems having different properties and drug release experiments were performed. For this purpose, gelatine, alpha-cellulose, clinoptilolite, modified clinoptilolite and 4-acryloyl morpholine (4 AcM) were combined with sodium alginate (NaAlg). Hydrogels were characterized by Fourier transform infrared spectroscopy (FT-IR) and digital microscope. In vitro drug release studies have been performed for Donepezil hydrochloride loaded hydrogels at pH 1.2, 6.8 and 7.4. The results showed that these hydrogels can be used for drug delivery systems.