Synthesis and electronic structure of new aryl- and alkyl-substituted 1,3,4-oxadiazole-2-thione derivatives


AYDOĞAN F. , Turgut Z. , Öcal N., Erdem S.

TURKISH JOURNAL OF CHEMISTRY, cilt.26, ss.159-169, 2002 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 26 Konu: 2
  • Basım Tarihi: 2002
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayısı: ss.159-169

Özet

New 5-alkyl and 3-(2,4-dimethylphenyl) substituted 1,3,4-oxadiazole-2-thione derivatives were synthesized by the ring closure reactions of various acylhydrazides with carbon disulphide. Mannich bases for some of these compounds were also synthesized by condensation with benzaldehyde and primary amines. All new compounds were characterized by spectral data. Most of them were tested for their antibacterial and antituberculostatic activity.