PRODUCTİON AND CHARACTERİZATİON OF BİOCOMPATİBLE WOUND DRESSİNGS BY ELECTROSPİNNİNG METHOD
VII. INTERNATIONAL ANKARA MULTIDISCIPLINARY STUDIES CONGRESS, Ankara, Türkiye, 5 - 06 Mart 2024, ss.1164-1165, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Ankara
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.1164-1165
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
Wounds have existed since the inception of life. In the present day, the increasing human population and disrupted balance of life have led to a higher incidence of both chronic and acute wounds. Materials
used as wound dressings include films, hydrogels, foams, nanofibers, and traditional bandages. In this study, nanofibers will be produced using the electrospinning method to contribute to the healing of
chronic wounds. These nanofibers will be compatible with the extracellular matrix (ECM), support cell growth, and possess antibacterial properties. Biocompatibility, toxicity, fiber size, and biodegradability
will be examined to evaluate the adequacy of the results for creating an environment conducive to wound healing. Green processes will be preferred, considering the rapid depletion and imbalance of our planet's
resources.Isolated soy protein (ISP) derived from soybeans, containing 98% protein, is a nature-friendly, water-soluble global plant protein structure. In this project, soy protein and the water-soluble biopolymer
Polyvinyl Alcohol (PVA) will be used as carrier polymers. PVA is widely used in membrane preparation, drug delivery systems, and tissue engineering due to its tissue-mimicking, flexibility, water absorption capability, gas permeability, and biocompatibility.Nanoparticles effectively promote wound
healing and provide antibacterial protection. Zinc oxide nanoparticles, produced through the sol-gel and hydrothermal methods, will be added to the prepared polymer solution in this study. Zinc oxide (ZnO),
a transition metal, exhibits excellent catalytic, electrical, photochemical, optical, and antibacterial properties. PVA:SPI:ZnO solutions with different compositions will undergo the electrospinning process, and optimum conditions will be achieved by experimenting with process parameters. The morphology and dimensions of the fibers will be characterized using SEM, the structure and phases of the fibers will be determined using XRD, and the chemical structure of the fibers will be analyzed using FTIR. The size of zinc oxide nanoparticles will be measured using a Zetasizer. Cytotoxicity analysis using MTT will be employed to measure cytotoxicity and proliferation. Additionally, In-Vitro Biodegradation analysis will be conducted to determine the time it takes for the fibers to degrade.
The authors are grateful for the financial support from YTU BAP under the contract numbers of FYL-2023- 5686.