Application of computer algebra matrix operation techniques to the control of metabolic networks


Bayram M.

APPLIED MATHEMATICS AND COMPUTATION, vol.152, no.1, pp.289-297, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1016/s0096-3003(03)00600-3
  • Title of Journal : APPLIED MATHEMATICS AND COMPUTATION
  • Page Numbers: pp.289-297

Abstract

In this paper we apply computer algebra (MAPLE) matrix operations and linear algebra facilities to analyze the control of metabolic networks. For this purpose, a computer program based on metabolic control theory was developed. When a stoichiometry matrix of the metabolic networks is given, the program calculates all the control coefficients (flux and metabolic control coefficients, summation and connectivity relationships) using elasticity coefficients. The program can be applied to any metabolic network which includes unlimited steps and intermediate metabolites. (C) 2003 Elsevier Inc. All rights reserved.