Especially in orthopedics and implant applications, the bone cements are the main pillar of implants to form permanent bonds with the body. However, the main risk factor for implants is infection and loosening of the implant over time. This situation can seriously compromise patient comfort and even patient life. Therefore, superior mechanical strength, biocompatibility and antimicrobial properties are required for comfortable and healthy use. In this study, antibacterial bone cements synthesized as bone filler for application in orthopedic surgeries. Compositon was conducted by synthesing polymethyl methacrylate in the presence of curcumin, polyhedral oligomeric silsesquioxane (POSS), hydroxyapatite and free radical curable PEG functional quaternary polyethylenimine and were analyzed by using the methods of X-ray diffraction, Fourier Transform Infrared Spectroscopy, dynamic mechanical analysis and scanning electron microscopy. The inhibition zone areas and the surface activity resistances of the bone cement composites were analyzed against the bacteriaEscherichia coli(E. coli),Listeria monositogenes(L. monositogenes),SalmonellaandStaphylococcus aureus(S. aureus). Biocompatibility analysis was also applied via MTS assay. Analysis results confirm the suitable surface biocidal activity along with high cells viability of curcumin and pegylated quaternary polyethylene based bone cement, indicating its potentials for orthopedic applications.