Journal Of Polymer Science Part A-Polymer Chemistry, vol.1, no.1, pp.1-13, 2020 (Journal Indexed in SCI Expanded)
Bacterial infection is a global problem, especially resistance acquired by bacteriaagainst to antibiotics; there is urgent need for the development of antibiotics.Here, we proposed dendron-grafted polymers via ring opening metathesispolymerization (ROMP) featuring different with tailored hydrophobicity/hydrophilicity and cationic charges. Dendritic oxanorbornene derivatives weresynthesized having two and six carbon linkers and their corresponding randomand block copolymers were prepared having pendant pyridinium salt moietiesvia ROMP. In total, 12 different water-soluble dendronized cationic polymersfeaturing hexyl pyridinium moieties were prepared and investigated. Six carbonlinker possessing triple charge density and hexyl pyridinium functionality eachrepeating unit copolymers exhibited high antibacterial activity against Gram-positive bacteria (S. aureus). However, all the polymers were inactive againstGram-negative bacteria (E. coli). Most of the copolymers are non-hemolytic(>HC50=1,000μg/ml). It was also observed that, there is no significant effectbetween block copolymers and random copolymers keeping hydrophobicity andcationic charge density constant. Zeta potential was measured to investigate themechanism in solution via the interaction of polymers withS. aureus,whilescanning electron microscope (SEM) measurements image confirms damage ofthe bacterial cell wall after implementation of biocidal polymer.