Akademik Veri Yönetim Sistemi
International Food Innovation and Sustainability Congress,, İstanbul, Türkiye, 16 - 18 Mayıs 2024, ss.202
Antibiotic resistance is on the rise among bacteria, posing significant challenges in treating infections and
increasing the development of bacterial resistance with each new antibiotic introduced. Pathogens such as
methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, carbapenem-resistant
Acinetobacter baumannii, cephalosporin-resistant Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis
can lead to severe infections, including sepsis. This study aims to assess the minimal antimicrobial concentrations
of aqueous extracts from various plants—Salvia officinalis L., Myrtus communis L., Laurus nobilis L. (Berry),
Laurus nobilis L. (Leaf), Hypericum perforatum L., Origanum onites L., Origanum sp., Origanum vulgare L.,
Sideritis, and resveratrol extracted from Polygonum cuspidatum—against drug-resistant bacteria and to formulate
the most effective mixtures. Aqueous extracts were obtained from these plants, and their minimal inhibition
concentrations (MIC) against drug-resistant bacteria were determined. The optimal mixture of plant extracts was
identified using the response surface method (RSM), and its inhibition effectiveness against drug-resistant bacteria
was tested on glass surfaces. The study demonstrated that plant extracts exhibited inhibitory effects on bacteria at
varying concentrations (ranging from 0.05% to 6%). Methicillin-resistant Staphylococcus aureus showed
sensitivity to herbal extracts among drug-resistant bacteria, while only resveratrol displayed inhibitory effects on
Escherichia coli, Acinetobacter baumannii, and Klebsiella pneumoniae ssp pneumoniae. Notably, Myrtus
communis L., Salvia officinalis L., and resveratrol exhibited the highest inhibition effects among the herbal
extracts. Utilizing the RSM, an effective mixture comprising 0.05% Myrtus communis L., 0.5% Salvia officinalis
L., and 0.5% resveratrol was identified against drug-resistant bacteria, completely inhibiting bacterial
concentrations of 5 log CFU/mL on glass surfaces. These findings suggest that herbal extracts can be utilized to
inhibit drug-resistant bacteria causing serious infections, with the Myrtus communis L., Salvia officinalis L., and
resveratrol mixture serving as a natural antimicrobial blend for surface disinfection.
Keywords: Antibiotic resistant microorganisms, medicinal plants, antimicrobial activity.