Akademik Veri Yönetim Sistemi
11. İlaç Kimyası Kongresi, Antalya, Türkiye, 9 Mart - 12 Nisan 2023, ss.92
Scientists are becoming more interested in creating coumarins because of the coumarins' highly useful
biological and medicinal capabilities. Lactone-class compounds known as coumarins or benzopyran-2-
ones was first discovered in Tonka beans in 1820. Since ancient times, these heterocyclic forms, which
are abundant in nature, have been employed as herbal medicines[1]. Numerous pharmacological
properties, including antibacterial, anti-inflammatory, anticancer, antiviral, antioxidant, antifungal,
anticoagulant are displayed by coumarins[2]. The piperazine ring, the most well-known N-heterocyclic
ring, occupies a special position in medicinal chemistry. Piperazines are currently receiving attention
in the search for novel medications because their derivatives have been reported to have a wide range
of pharmacological activities[3].Triazoles, which draw interest due to their applications, have succeeded
in capturing the spotlight since the advent of click chemistry. Triazoles have developed into significant
functional groups that serve as multiple binders as a result of click reactions. The powerful, extremely
dependable, and selective copper(I)-catalyzed azide-alkyne cycloaddition allows for the quick synthesis
of novel chemicals that are beneficial to science[4]. The characteristics of the parent substance are
altered when another heterocyclic moiety is incorporated into coumarin as a substituent or as a fused
component, and the resultant compounds frequently display promising or even novel biological
capabilities. In this study, a serie of novel triazole-tethered piperazine coumarin hybrids with the
potential to display a variety of biological activities were synthesized by click chemistry approach.