Design and Synthesis of Novel Triazole-Tethered Piperazine Coumarin Hybrids

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Arvas B., Aydoğan F., Yolaçan Ç.

11. İlaç Kimyası Kongresi, Antalya, Turkey, 9 March - 12 April 2023, pp.92

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.92
  • Yıldız Technical University Affiliated: Yes


Scientists are becoming more interested in creating coumarins because of the coumarins' highly useful biological and medicinal capabilities. Lactone-class compounds known as coumarins or benzopyran-2- ones was first discovered in Tonka beans in 1820. Since ancient times, these heterocyclic forms, which are abundant in nature, have been employed as herbal medicines[1]. Numerous pharmacological properties, including antibacterial, anti-inflammatory, anticancer, antiviral, antioxidant, antifungal, anticoagulant are displayed by coumarins[2]. The piperazine ring, the most well-known N-heterocyclic ring, occupies a special position in medicinal chemistry. Piperazines are currently receiving attention in the search for novel medications because their derivatives have been reported to have a wide range of pharmacological activities[3].Triazoles, which draw interest due to their applications, have succeeded in capturing the spotlight since the advent of click chemistry. Triazoles have developed into significant functional groups that serve as multiple binders as a result of click reactions. The powerful, extremely dependable, and selective copper(I)-catalyzed azide-alkyne cycloaddition allows for the quick synthesis of novel chemicals that are beneficial to science[4]. The characteristics of the parent substance are altered when another heterocyclic moiety is incorporated into coumarin as a substituent or as a fused component, and the resultant compounds frequently display promising or even novel biological capabilities. In this study, a serie of novel triazole-tethered piperazine coumarin hybrids with the potential to display a variety of biological activities were synthesized by click chemistry approach.