SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND PHENOBARBITAL IN SUPPOSITORIES BY PARTIAL LEAST-SQUARES SPECTROPHOTOMETRIC CALIBRATION


BOZDOGAN A. E. , KUNT G. , ACAR A.

ANALYTICAL LETTERS, vol.25, no.11, pp.2051-2058, 1992 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 11
  • Publication Date: 1992
  • Doi Number: 10.1080/00032719208020074
  • Title of Journal : ANALYTICAL LETTERS
  • Page Numbers: pp.2051-2058

Abstract

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of suppositories in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and phenobarbital in suppository preparations. The results show that these components in a molar ratio of about 61:1 in suppositories have been determined simultaneously with high precision.