SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN AND PHENOBARBITAL IN SUPPOSITORIES BY PARTIAL LEAST-SQUARES SPECTROPHOTOMETRIC CALIBRATION


BOZDOGAN A. E. , KUNT G. , ACAR A.

ANALYTICAL LETTERS, cilt.25, ss.2051-2058, 1992 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 25 Konu: 11
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1080/00032719208020074
  • Dergi Adı: ANALYTICAL LETTERS
  • Sayfa Sayısı: ss.2051-2058

Özet

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of suppositories in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and phenobarbital in suppository preparations. The results show that these components in a molar ratio of about 61:1 in suppositories have been determined simultaneously with high precision.