Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections

Kesim-Sahin O., Sirin N. G., Erbas B., Artug T., Oguz-Akarsu E., Kocasoy-Orhan E., ...Daha Fazla

Muscle and Nerve, cilt.62, sa.2, ss.239-246, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/mus.26923
  • Dergi Adı: Muscle and Nerve
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.239-246
  • Anahtar Kelimeler: CMAP scan, MScanFit, MUNE, peripheral nerve injury, stimulus response curve, Wallerian degeneration
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

Background: Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT). Methods: Beginning after urgent surgery, CMAP scans were recorded at 1–2 day intervals in 12 patients with ANT of the ulnar or median nerves, by stimulating the distal stump (DS). Stimulus intensities (SI), steps, returners, and MScanFit were calculated. Studies were grouped according to the examination time after ANT. Results were compared with those of 27 controls. Results: CMAP amplitudes and MScanFit progressively declined, revealing a positive correlation with one another. SIs were higher in WD groups than controls. Steps appeared or disappeared in follow-up scans. The late WD group had higher returner% than the early WD and control groups. Conclusions: MScanFit can monitor neuromuscular dysfunction during WD. SIs revealed excitability changes in DS.