Poly(azomethine) Based Micelles for Delivery of Caffeic Acid Phenethyl Ester

Topuzogullari N. S., Poyraz F. Ş., Topuzogullari M., Mansuroğlu B.

Polymer (Korea), vol.49, no.3, pp.277-284, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2025
  • Doi Number: 10.7317/pk.2025.49.3.277
  • Journal Name: Polymer (Korea)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Page Numbers: pp.277-284
  • Keywords: drug delivery, micelle, pH-sensitive, polyazomethine, polyimine
  • Yıldız Technical University Affiliated: Yes

Abstract

Poly(azomethine) based micelles have been developed for the delivery of caffeic acid phenethyl ester (CAPE). These micelles, synthesized from a polyazomethine-PEG block copolymer, demonstrate significant potential in drug release systems due to its pH-sensitive biodegradable nature. Characterization through SEM revealed spherical micelles with an average diameter of 135.5 nm. The micelles' drug release behavior was studied at physiological (pH 7.2) and lyso-somal (pH 5.0) pH levels. The findings indicated pH sensitive release of CAPE from the micelle of which only 2.14% of CAPE was released at pH 7.2 while 38.8% of CAPE was released at pH 5.0 after 24 h. In vitro cell viability assays using human-derived fibroblast cells showed that CAPE-loaded micelles exhibited minimal toxicity after 48 hours compared to CAPE and free micelle. These results suggest the potential of polyazomethine-based micelles as efficient carriers for targeted drug delivery for therapeutic purposes.