This paper focuses on the exergetic sustainability indicators of a medium-range commercial aircraft engine for constant reference environment and ground running conditions. First, a detailed exergy analysis of turbofan engine have been performed based on engine test cell parameters. Starting from the sustainability considerations and the second law of the thermodynamics, the paper presents six exergy-based sustainability indicators. The indicators of the turbofan engine developed here in conjunction with exergetic analysis and sustainable development are exergy efficiency, waste exergy ratio, exergy destruction factor, recoverable exergy rate, environmental effect factor, and exergetic sustainability index. The investigated sustainable indicators have been calculated by using exergy analysis outputs for aircraft ground running condition. Results from this study show that values of exergy efficiency, waste exergy ratio, exergy destruction factor, recoverable exergy rate, environmental effect factor, and exergetic sustainability index of investigated turbofan engine are found to be 0.315, 0.685, 0.408, 0, 2.174, and 0.460, respectively. These parameters are expected to quantify how the turbofan engine and aircraft become more environmentally benign and sustainable.