The Role of MicroRNAs (MiRNAs) in Neurodegenerative Diseases

Şahin K. N., Sever T., Aktaş E., Özdemir Özgentürk N.

in: THE BROAD SPECTRUM OF BIOLOGICAL SCIENCES, Dr. Sevgi MARAKLI,Dr. Merve YILMAZER, Editor, Gaziantep University Press, Gaziantep, pp.475-491, 2024

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2024
  • Publisher: Gaziantep University Press
  • City: Gaziantep
  • Page Numbers: pp.475-491
  • Editors: Dr. Sevgi MARAKLI,Dr. Merve YILMAZER, Editor
  • Yıldız Technical University Affiliated: Yes

Abstract

Neurodegenerative diseases have become a significant public health issue today, characterized by complex etiology, diagnosis, and treatment. Recent research highlights the critical role of microRNAs (miRNAs) in the pathogenesis of neurodegenerative diseases. Abnormal miRNA expression observed in conditions such as Alzheimer's, Parkinson's, Huntington's, and Multiple Sclerosis emphasizes their importance in disease mechanisms. As a result, exploring miRNAs as potential biomarkers for diagnosing, prognosis, and treating these disorders has emerged as a vital research area. However, further studies are necessary to develop and transition miRNA-based therapies into clinical practice. Advances in this field may lead to more effective diagnostic and therapeutic strategies for neurodegenerative diseases. This study examines the potential role of miRNAs in the pathogenesis of neurodegenerative diseases and their viability as biomarkers for these conditions.