ANTIOXIDANT EFFECT OF CATECHIN LOADED POLYMERIC NANOPARTICLE

Tuncer B., Mansuroğlu B., Derman S.

SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI, cilt.34, sa.3, ss.453-465, 2016 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2016
  • Dergi Adı: SIGMA JOURNAL OF ENGINEERING AND NATURAL SCIENCES-SIGMA MUHENDISLIK VE FEN BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals
  • Sayfa Sayıları: ss.453-465
  • Anahtar Kelimeler: Nanoparticle, catechin, antioxidant activity, polymeric nanoparticle, GREEN TEA CATECHINS, IN-VITRO, PLGA NANOPARTICLES, BIODEGRADABLE NANOPARTICLES, POLYPHENOLIC CATECHINS, CELLULAR UPTAKE, PARTICLE-SIZE, DRUG-RELEASE, BLACK TEA, VIVO
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Flavonoids are polyphenols compounds a structural class of mainly natural and a products of secondary metabolism of plants. Flavonoids, which can be found in herbs and trees, act as natural chemopreventives and anticancer agents [1]. As natural products, they have major importance for human life and also have a widespread effect such as antioxidant, antinflammatory, anticarcinogen, antidiabetic [2, 3]. However, bioavailability of this polyphenolic antioxidant have limited because of their high water solubility [4], low absorption, permeability, stability, slow dissolution rate, and light-induced decomposition over time in the physiological medium. In recent years, various methods have been tried to overcome the limitations of flavonoids, including its incorporation into micels and nanoparticles.