Parkin level in plasma of ALS patients

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Günel A., Vural Korkut Ş., Çelik R., İdrisoğlu H. A.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, vol.22, pp.105, 2021 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2021
  • Journal Name: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.105
  • Yıldız Technical University Affiliated: Yes

Abstract

Accumulation of misfolded and damaged pro-

teins are known to be associated with the pathogenesis of

many   neurodegenerative   diseases   such   as   Parkinson ’ s

Disease, Alzheimer Disease, ALS (1 – 4). Parkin, an E3 ubiquitin-

protein ligase, is an important component of ubiquitin-prote-

asome  system  (5).  It  is  known  that  Parkin  is  important  for

especially  genetic  Parkinsonism.  There  is  limited  study  on

Parkin for ALS disease.