Akademik Veri Yönetim Sistemi
I. International Advances in Molecular Biology Congress, İstanbul, Türkiye, 19 - 22 Eylül 2022, ss.94
Indole
derivatives with a wide spectrum of biological activity, especially anticancer,
antiviral, antimicrobial, anti-inflammatory, anti-HIV, antidiabetic activities;
as an active drug substance, it is among the compounds of interest for the
pharmaceutical industry and the pharmaceutical industry. Indole derivatives,
which have the characteristics of a typical nitrogen heterocyclic compound, can
be obtained synthetically by biotransformation reactions as well as being found
in nature. Biotransformation reactions are using various enzymes or
microorganisms; They are reactions that can take place under mild conditions,
which have advantages over chemical synthesis methods (cheap, fast, efficient).
It allows the compounds in racemic form to be obtained as enantiopure by
biotransformation reactions. In our study, it was aimed to obtain indole
derivatives with high enantiopurity, which are difficult to synthesize by
chemical methods, under mild synthesis conditions. In this study, 1-benzyl-6,7-dihydro
6-methyl-1H-indol-4(5H)-one compound was synthesized as a result of various
synthesis steps starting from 5-methyl-1,3-cyclohexadione compound. In the next
step, regioselective acetoxylation of
1-benzyl-6,7-dihydro-6-methyl-1H-indol-4(5H)-one was performed and as a result
of the addition of acetoxy group to the α position, the compound α-acetoxy-1
benzyl-6,7-dihydro-6-methyl-1H-indol-4(5H)-one was obtained. The
biotransformation reactions of the obtained indole derivatives will be carried
out and the enantiomeric excess values of the products obtained as enantiopure
will be determined by HPLC.