Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives

KARATAŞ M. O., ALICI B., Cetinkaya E., Bilen C., Gencer N., Arslan O.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, cilt.40, sa.4, ss.461-466, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1134/s1068162014040049
  • Dergi Adı: RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.461-466
  • Anahtar Kelimeler: benzimidazole, enzymatic browning, tyrosinase inhibitors, EGGPLANT POLYPHENOL OXIDASE, MUSHROOM TYROSINASE, ANTIBROWNING AGENTS, MOLECULAR DESIGN, PURIFICATION, ACID, CATECHOLASE, COMPLEXES, CATALYST
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, H-1 NMR, C-13 NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzo[d]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM).