RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol.40, no.4, pp.461-466, 2014 (SCI-Expanded)
Article / Article
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
benzimidazole, enzymatic browning, tyrosinase inhibitors, EGGPLANT POLYPHENOL OXIDASE, MUSHROOM TYROSINASE, ANTIBROWNING AGENTS, MOLECULAR DESIGN, PURIFICATION, ACID, CATECHOLASE, COMPLEXES, CATALYST
Yıldız Technical University Affiliated:
1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, H-1 NMR, C-13 NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzo[d]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM).