Sono-photodynamic Therapy Studies on Phthalocyanines

Yaşa Atmaca G.

1. ULUSLARARASI MALATYA UYGULAMALI BİLİMLER KONGRESİ, Malatya, Turkey, 20 - 22 December 2019, pp.61-66

  • Publication Type: Conference Paper / Full Text
  • City: Malatya
  • Country: Turkey
  • Page Numbers: pp.61-66
  • Yıldız Technical University Affiliated: Yes


In recent years, there have been significant developments in the treatment of cancer. Traditional therapies such as surgery, radiotherapy and chemotherapy have led to great success in clinical control, but they also have serious side effects. Therefore, novel therapies are needed to improve the life quality of the patient. By combining SDT and PDT has been demonstrated that this novel approach can lower the side effects caused by sensitizer.

In this study, it is desired to apply the above mentioned SPDT method to create a more effective therapeutic outcome. Thus, the SPDT property of 4-[(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decylthio)phenoxy] phthalocyaninato Zn(II) and Co(II) examined in THF. The results showed that the singlet oxygen yields of the complexes in the SPDT method are almost twice higher than the singlet oxygen yields in the PDT method.