Akademik Veri Yönetim Sistemi
1. INTERNATIONAL ÜSKÜDAR SCIENTIFIC RESEARCH AND INNOVATION CONGRESS, İstanbul, Türkiye, 19 - 20 Temmuz 2024, ss.1
The chalcones containing two aromatic rings (1,3-diaryl-2-propen-1-ones) consist of a three-carbon α,β-unsaturated carbonyl system. These structures are flavonoids and isoflavonoids. The chalcones, a subgroup of flavonoids, attract much attention with their antioxidant, antiviral and anticarcinogenic activities due to their chemical structures. Studies on this subject are very important from a pharmacological perspective, both in terms of the isolation of flavonoids from plants and their chemical modifications.
In this study, the synthesis of 9 substitued the chalcon that could show biological activity was carried out using the base-catalyzed (KOH) Claisen-Schmidt method in EtOH. In the first stage, acetophenone derivatives were dissolved in ethanol and aldehyde derivatives were added. The solution was mixed in a magnetic stirrer (700 rpm) at 25 0C, for 90-120 minutes by creating a basic environment. The reaction was controlled by TLC using the appropriate solvent system for each compound. According to these results, the reaction was terminated and waited for 16 hours. It was acidified with 10% HCl solution. It was washed with pure water, filtered and dried. The column chromatography was applied to purify the products. In the second stage, the synthesized products were mixed with cyclohexanone under the same conditions. The structure of all synthesized products was elucidated by spectroscopic methods (FTIR, NMR and GC/MS).