THE SYNTHESIS OF NEW COUMARIN DERIVATIVES

INTERNATIONAL CONGRESS OF NEW HORIZONS IN SCIENCES, İstanbul, Türkiye, 20 - 21 Mayıs 2023, ss.39

In these days, the usage of coumarins as bactericides, fungicides, anti-inflammatory, anticoagulant, and

antitumor medicines makes them a significant group of chemical substances [1]. Pharmacological

characteristics of these compounds inspired interest of chemists in creating a variety of novel compounds

with various heterocyclic rings fused to the coumarin moiety in an effort to produce more potent coumarins

that are pharmacologically active. Due to their varied biological actions, triazoles, which include 1,2,3-

triazole and 1,2,4-triazole as well as coumarins, play a significant role in medicinal chemistry. Some of these

compounds have even been utilized in clinical studies [2]. Because of its dependability, selectivity, and

biocompatibility, the copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal

alkynes has emerged as the gold standard of "click chemistry." The triazole compounds are more than

basically inert linkers; through hydrogen bonds and interactions between dipole-dipole, they easily bind to

biological targets [3]. In this work, triazole-coumarin hybrid compounds with the ability to display a variety

of biological activities were synthesized based on three different coumarin motifs, and their structures were

identified by their spectral data.