Numerical solutions of the generalized Burgers-Huxley equation are obtained using a polynomial differential quadrature method with minimal computational effort. To achieve this, a combination of a polynomial-based differential quadrature method in space and a low-storage third-order total variation diminishing Runge-Kutta scheme in time has been used. The computed results with the use of this technique have been compared with the exact solution to show the required accuracy of it. Since the scheme is explicit, linearization is not needed and the approximate solution to the nonlinear equation is obtained easily. The effectiveness of this method is verified through illustrative examples. The present method is seen to be a very reliable alternative method to some existing techniques for such realistic problems. Copyright (C) 2009 M. Sari and G. Gurarslan.