2nd International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2020), Gaziantep, Turkey, 7 - 09 October 2020, pp.1-4
Synthesis of Thiophen Substitue 5,6-Dihydrobenzoquinazolin-2-amine
Compounds
F.Tülay TUĞCU
Yildiz Technical University, Faculty of Science, Department of Chemistry
The benzoquinazoline ring is one of the most investigated scaffolds
in medicinal chemistry. This group of compounds
exhibits numerous pharmacological activities such as anti-inflammatory, antimicrobial,
analgesic, diuretic, antihypertensive, antibiotic and antitumoral properties
and many benzoquinazolines have been demonstrated to inhibit kinases by
competing with ATP for the kinase active site.
Therefore, in this study, some new substituted benzoquinazoline derivatives which are considered that may possess biological
activity have been obtained via one-pot multicomponent method by using substitute-thiophen
carboxaldehydes, guanidine carbonate and 1-tetralone; and the structures of all these
synthesized compounds have been clarified with spectral
data.
Thanks for Yıldız Technical University Scientific Research Projects Coordination's support in this study. Project No: 2012-01-02-GEP05.
Synthesis of Thiophen Substitue 5,6-Dihydrobenzoquinazolin-2-amine
Compounds
F.Tülay TUĞCU
Yildiz Technical University, Faculty of Science, Department of Chemistry
The benzoquinazoline ring is one of the most investigated scaffolds
in medicinal chemistry. This group of compounds
exhibits numerous pharmacological activities such as anti-inflammatory, antimicrobial,
analgesic, diuretic, antihypertensive, antibiotic and antitumoral properties
and many benzoquinazolines have been demonstrated to inhibit kinases by
competing with ATP for the kinase active site.
Therefore, in this study, some new substituted benzoquinazoline derivatives which are considered that may possess biological
activity have been obtained via one-pot multicomponent method by using substitute-thiophen
carboxaldehydes, guanidine carbonate and 1-tetralone; and the structures of all these
synthesized compounds have been clarified with spectral
data.
Thanks for Yıldız Technical University Scientific Research Projects Coordination's support in this study. Project No: 2012-01-02-GEP05.