BIOMECHANICAL ANALYSIS OF BREAST CANCER CELLS: A COMPARATIVE STUDY OF INVASIVE AND NON-INVASIVE CELL LINES USING DIGITAL HOLOGRAPHIC MICROSCOPY

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Işik Y., Abdioğlu H. B.

Deney Föyü, ss.1-6, 2023

  • Yayın Türü: Diğer Yayınlar / Deney Föyü
  • Basım Tarihi: 2023
  • Sayfa Sayıları: ss.1-6
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Abstract—This study investigates the biomechanical properties

of breast cancer cells, focusing on the invasive MDA-MB-231

and non-invasive MCF-7 cell lines, using phase-shifting digital

holographic microscopy and an acousto-holographic system for

non-invasive strain measurement. Findings reveal higher strain

values in MDA-MB-231 cells, indicative of their aggressive,

metastatic nature, compared to lower strain values in MCF-7

cells. This variance in mechanical properties, potentially linked

to distinct metabolic states and responses to external stimuli,

underscores the role of cellular mechanics in cancer progression.

The study advances understanding of breast cancer cell mechan-

ics, highlighting biomechanical analysis as a crucial tool in cancer

research and potential therapeutic interventions.