An overview of challenges to eradication of Helicobacter pylori infection and future prospects

BAĞIROVA M., ALLAHVERDİYEV A., ABAMOR E. Ş., ALIYEVA H., UNAL G., Tanalp T. D.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.21, no.9, pp.2199-2219, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 9
  • Publication Date: 2017
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2199-2219
  • Keywords: H. pylori, Infection, Eradication, Diagnosis, Vaccination, Dental plaque, Oral cavity, GASTRIC EPITHELIAL-CELLS, POLYMERASE-CHAIN-REACTION, PROTON PUMP INHIBITOR, KAPPA-B ACTIVATION, DENTAL PLAQUE, ORAL-CAVITY, TRIPLE THERAPY, HIGH PREVALENCE, MICROCULTURE METHOD, RESCUE THERAPIES
  • Yıldız Technical University Affiliated: Yes

Abstract

The eradication of H. pylori infection continues to be a challenge due to the evolution of drug-resistant bacteria, lack of a gold standard diagnostic method, and ineffectiveness of current vaccines. Additionally, there still is no consensus in the literature about the main source of gastric H. pylori infection. The bacterium has also been demonstrated to colonize in dental plaque and the oral cavity. We believe that to develop new approaches for successful eradication of the disease, factors such as the biology of the bacterium, reservoir differentiations, host-bacterium interactions and problems in diagnosis, treatment and vaccination must be comprehensively considered.