Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasis
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.12, sa.8, ss.353-364, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 8
- Basım Tarihi: 2019
- Doi Numarası: 10.4103/1995-7645.262564
- Dergi Adı: ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.353-364
- Anahtar Kelimeler: Visceral leishmaniasis, Vaccine, Delivery, Immunostimulant, Poly lactic-co-glycolic acid (PLGA), Nanoparticle, NITRIC-OXIDE PRODUCTION, CPG ODNS INDUCE, PLGA NANOPARTICLES, MURINE MODEL, PROTECTION
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
Objective: To prepare and characterize poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with soluble leishmanial antigen or autoclaved leishmanial antigen and explore in vitro and in vivo immunogenicity of antigen encapsulated nanoparticles.