Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasis

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Atıf İçin Kopyala

Abamor E. Ş., Allahverdiyev A., Tosyali O. A., Bağırova M., Acar T., Mustafaeva Z., ...Daha Fazla

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, cilt.12, sa.8, ss.353-364, 2019 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 12 Sayı: 8
• Basım Tarihi: 2019
• Doi Numarası: 10.4103/1995-7645.262564
• Dergi Adı: ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.353-364
• Anahtar Kelimeler: Visceral leishmaniasis, Vaccine, Delivery, Immunostimulant, Poly lactic-co-glycolic acid (PLGA), Nanoparticle, NITRIC-OXIDE PRODUCTION, CPG ODNS INDUCE, PLGA NANOPARTICLES, MURINE MODEL, PROTECTION
• Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Objective: To prepare and characterize poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with soluble leishmanial antigen or autoclaved leishmanial antigen and explore in vitro and in vivo immunogenicity of antigen encapsulated nanoparticles.