Evaluation of in vitro and in vivo immunostimulatory activities of poly (lactic-co-glycolic acid) nanoparticles loaded with soluble and autoclaved Leishmania infantum antigens: A novel vaccine candidate against visceral leishmaniasis


Abamor E. Ş. , Allahverdiyev A. , Tosyali O. A. , Bağırova M. , Acar T., Mustafaeva Z., ...More

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, vol.12, no.8, pp.353-364, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 8
  • Publication Date: 2019
  • Doi Number: 10.4103/1995-7645.262564
  • Title of Journal : ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
  • Page Numbers: pp.353-364
  • Keywords: Visceral leishmaniasis, Vaccine, Delivery, Immunostimulant, Poly lactic-co-glycolic acid (PLGA), Nanoparticle, NITRIC-OXIDE PRODUCTION, CPG ODNS INDUCE, PLGA NANOPARTICLES, MURINE MODEL, PROTECTION

Abstract

Objective: To prepare and characterize poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with soluble leishmanial antigen or autoclaved leishmanial antigen and explore in vitro and in vivo immunogenicity of antigen encapsulated nanoparticles.