Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method


Ciftci F., DUYGULU N. , Yilmazer Y., GÜNDÜZ O., ÜSTÜNDAĞ C. B.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2021.2008391
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Keywords: Antioxidant, carvacrol, drug, electrospinning, essential oil, polymer nanofiber, thymol, ESSENTIAL OIL, IN-VITRO, ANTIOXIDANT, EXTRACT, GROWTH, BOISS.

Abstract

In this study, poly(lactic-acid) (PLA) polymer-based nanofiber (NF) was obtained by the electrospinning method. Antioxidant Zataria Multiflora (ZM, essential oil extract) and antibiotic effective bacitracin (BAC) materials were added to 8% PLA. ZM essential oil was extracted with Rotary and antioxidant components were investigated using GC-MS. While carvacrol constitutes 50% as the main component of ZM, it was seen as 48.06% carvacrol and 25.47% thymol as a content area. It was analyzed that ZM has a total antioxidant rate of 99.87% with 20 components. In antibacterial tests, PLA/BAC/ZM NF showed the best inhibition growth on all microorganisms (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Staphylococcus epidermidis, Bacillus subtilis). In cell XTT cytotoxicity tests, it was observed that the PLA/BAC/ZM NF used in adhesion and 4 ',6-diamidino-2-phenylindole (DAPI) results showed very good adhesion to cells.