Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method

Ciftci F., DUYGULU N., Yilmazer Y., GÜNDÜZ O., ÜSTÜNDAĞ C. B.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.72, no.4, pp.319-334, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1080/00914037.2021.2008391
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.319-334
  • Keywords: Antioxidant, carvacrol, drug, electrospinning, essential oil, polymer nanofiber, thymol, ESSENTIAL OIL, IN-VITRO, ANTIOXIDANT, EXTRACT, GROWTH, BOISS.
  • Yıldız Technical University Affiliated: Yes


In this study, poly(lactic-acid) (PLA) polymer-based nanofiber (NF) was obtained by the electrospinning method. Antioxidant Zataria Multiflora (ZM, essential oil extract) and antibiotic effective bacitracin (BAC) materials were added to 8% PLA. ZM essential oil was extracted with Rotary and antioxidant components were investigated using GC-MS. While carvacrol constitutes 50% as the main component of ZM, it was seen as 48.06% carvacrol and 25.47% thymol as a content area. It was analyzed that ZM has a total antioxidant rate of 99.87% with 20 components. In antibacterial tests, PLA/BAC/ZM NF showed the best inhibition growth on all microorganisms (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Staphylococcus epidermidis, Bacillus subtilis). In cell XTT cytotoxicity tests, it was observed that the PLA/BAC/ZM NF used in adhesion and 4 ',6-diamidino-2-phenylindole (DAPI) results showed very good adhesion to cells.