In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers


Taskin M. I. , Bilen C. , Ergun A., Gencer N., Inceboz U.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, vol.78, no.9, pp.513-519, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jcma.2015.03.014
  • Title of Journal : JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
  • Page Numbers: pp.513-519
  • Keywords: carbonic anhydrases, enzyme inhibition, estrogens, progestagens, MICRONIZED PROGESTERONE, INHIBITORS, SULFONAMIDES, DERIVATIVES, DIENOGEST, ENZYME

Abstract

Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion in various tissues, bone resorption and calcification, and tumorigenicity. In the current study, we aimed to determine and compare possible alterations in the activity of carbonic anhydrase I (CA I) and carbonic anhydrase II (CA II) isozymes by using estrogens and progestagens in female smokers and nonsmokers.