In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers

Taskin M. I., Bilen C., Ergun A., Gencer N., Inceboz U.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, cilt.78, sa.9, ss.513-519, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jcma.2015.03.014
  • Dergi Adı: JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.513-519
  • Anahtar Kelimeler: carbonic anhydrases, enzyme inhibition, estrogens, progestagens, MICRONIZED PROGESTERONE, INHIBITORS, SULFONAMIDES, DERIVATIVES, DIENOGEST, ENZYME
  • Yıldız Teknik Üniversitesi Adresli: Hayır

Özet

Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion in various tissues, bone resorption and calcification, and tumorigenicity. In the current study, we aimed to determine and compare possible alterations in the activity of carbonic anhydrase I (CA I) and carbonic anhydrase II (CA II) isozymes by using estrogens and progestagens in female smokers and nonsmokers.