In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers

Taskin M. I., Bilen C., Ergun A., Gencer N., Inceboz U.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, vol.78, no.9, pp.513-519, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 78 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jcma.2015.03.014
  • Journal Name: JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.513-519
  • Keywords: carbonic anhydrases, enzyme inhibition, estrogens, progestagens, MICRONIZED PROGESTERONE, INHIBITORS, SULFONAMIDES, DERIVATIVES, DIENOGEST, ENZYME
  • Yıldız Technical University Affiliated: No

Abstract

Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion in various tissues, bone resorption and calcification, and tumorigenicity. In the current study, we aimed to determine and compare possible alterations in the activity of carbonic anhydrase I (CA I) and carbonic anhydrase II (CA II) isozymes by using estrogens and progestagens in female smokers and nonsmokers.