Analysis of pesticide residues in hazelnuts using the QuEChERS method by liquid chromatography–tandem mass spectrometry

ÇEBİ N., Manav O. G., Olgun E. O.

Microchemical Journal, vol.166, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 166
  • Publication Date: 2021
  • Doi Number: 10.1016/j.microc.2021.106208
  • Journal Name: Microchemical Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Food Science & Technology Abstracts, Index Islamicus, Veterinary Science Database
  • Keywords: Hazelnut, QuEChERS, Pesticide, LC-MS, MS, Food safety, SOLID-PHASE EXTRACTION, SAMPLE PREPARATION, FOODS, NUTS
  • Yıldız Technical University Affiliated: Yes


© 2021 Elsevier B.V.An analytical methodology to efficiently monitor 77 pesticides in hazelnut samples has been developed in this research for the first time. A QuEChERS (quick, easy, effective, rugged, and safe) sample preparation was applied with a liquid chromatography tandem mass spectrometry (LC-MS/MS) methodology. Validation of the methodology was performed in accordance with SANTE/11945/2015. Favorable validation coefficient (0.99), limit of detection (LOD) (2–11 µg/kg), limit of quantification (LOQ) (4–37 µg/kg), recovery (64–130%), repeatability (1–18%) and reproducibility (4–28%) values were obtained. Samples of real hazelnuts were successfully tested using this methodology. Acetochlor, boscalid, carbendazm, chlorantraniliprole, chloridazon, diflubenzuron, fenarimol and fluopyram pesticide residues were detected in commercial hazelnuts. The quantities of these residues were significantly lower than MRLs which were published by the European Union (EU). The findings indicate that the current method can be used effectively for multi-pesticide residue control of hazelnuts by the food control institutions of governments.