Complexation of ibuprofen with water soluble p-sulfonatocalix [4] arene: A potential candidate for drug delivery application


Khokhar T. S. , Memon S., Panhwar Q. K. , Memon F. N. , Memon A. A. , Samejo M. Q. , et al.

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.30, ss.783-788, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2017
  • Dergi Adı: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayısı: ss.783-788

Özet

Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. Delta Q Delta H and Delta S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.