Complexation of ibuprofen with water soluble p-sulfonatocalix [4] arene: A potential candidate for drug delivery application

Khokhar T. S., Memon S., Panhwar Q. K., Memon F. N., Memon A. A., Samejo M. Q., ...More

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.30, no.3, pp.783-788, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2017
  • Journal Name: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.783-788
  • Keywords: Synthesis, inclusion complex, p-sulfonatocalix[4]arene, thermodynamic, drug delivery, RELEASE, RECOGNITION, CALIXARENES, DERIVATIVES
  • Yıldız Technical University Affiliated: Yes

Abstract

Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. Delta Q Delta H and Delta S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.