Complexation of ibuprofen with water soluble p-sulfonatocalix [4] arene: A potential candidate for drug delivery application
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.30, sa.3, ss.783-788, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 3
- Basım Tarihi: 2017
- Dergi Adı: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.783-788
- Anahtar Kelimeler: Synthesis, inclusion complex, p-sulfonatocalix[4]arene, thermodynamic, drug delivery, RELEASE, RECOGNITION, CALIXARENES, DERIVATIVES
- Yıldız Teknik Üniversitesi Adresli: Evet
Özet
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. Delta Q Delta H and Delta S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.