A spectrophotometric method for the determination of prazosin hydrochloride in tablets

Özgür M., Sungur S.

REVIEWS IN ANALYTICAL CHEMISTRY, cilt.22, sa.1, ss.1-8, 2003 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2003
  • Dergi Adı: REVIEWS IN ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-8
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin hydrochloride. The method is based on the formation of a coloured derivative between the drug and 1,2-naphthoquinone-4-sulfonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH = 4.5 and 70degreesC in 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the absorbance was measured at 400 nm. The method was applied to commercially available tablets and the results were statistically compared with those obtained by ultraviolet spectrophotometric and differential pulse polarographic methods using t- and F-tests.