Synthetic peptide vaccine for Foot-and- Mouth Disease: synthesis, characterization and immunogenicity


MANSUROĞLU B. , DERMAN S. , Kizilbey K., Ates S. C. , Akdeste Z. M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.6, pp.859-868, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.1515/tjb-2020-0110
  • Title of Journal : TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Page Numbers: pp.859-868

Abstract

Background: The conjugations of antigenic synthetic peptide sequences with carrier polymers have opened new possibilities for the treatment of diseases. In this study, 135-161 peptide sequence of VP1 capsid protein of Foot-and-Mouth Disease was cross-linked with P(VP-co-AA) copolymer by covalent conjugation using water-soluble carbodiimide at different ratio of components (gamma=5, 7, 9, 11, 15) for the first time in the literature.