Synthetic peptide vaccine for Foot-and- Mouth Disease: synthesis, characterization and immunogenicity
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.6, pp.859-868, 2020 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 45 Issue: 6
- Publication Date: 2020
- Doi Number: 10.1515/tjb-2020-0110
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Page Numbers: pp.859-868
- Open Archive Collection: AVESIS Open Access Collection
- Yıldız Technical University Affiliated: Yes
Abstract
Background: The conjugations of antigenic synthetic peptide sequences with carrier polymers have opened new possibilities for the treatment of diseases. In this study, 135-161 peptide sequence of VP1 capsid protein of Foot-and-Mouth Disease was cross-linked with P(VP-co-AA) copolymer by covalent conjugation using water-soluble carbodiimide at different ratio of components (gamma=5, 7, 9, 11, 15) for the first time in the literature.