Production of microneedle patches coated with polyvinyl-alcohol/sucrose/gentamicin sulfate for skin treatment

Mutlu M. E., Akdag Z., Pilavci E., ULAĞ S., DAĞLILAR S., GÜNDÜZ O.

Materials Letters, vol.378, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 378
  • Publication Date: 2025
  • Doi Number: 10.1016/j.matlet.2024.137557
  • Journal Name: Materials Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: 3D printing, Biomaterials, Digital light processing (DLP), Gentamicin sulfate, Microneedle, Polyvinyl alcohol (PVA), Sucrose
  • Yıldız Technical University Affiliated: Yes

Abstract

In this study, resin-based microneedle (MN) patches were fabricated using a digital light processing (DLP) printer. The needles were coated with gentamicin sulfate (GEN)-loaded with 13.3 % PVA/25 % sucrose solution by immersion. The SEM results showed that the coating was homogeneous and uniformly conical. Analysing the in vitro release profiles of GEN, it was found that it was ultimately released within 312 h. The compression test results demonstrated that GEN addition increased the compression strength to the value of 2.17 ± 0.01 N/mm2.