Akademik Veri Yönetim Sistemi
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.16, sa.3, ss.615-632, 2023 (Hakemli Dergi)
Posaconazole (PCZ) is an antifungal agent and its absorption is difficult due to its low solubility in aqueous and acidic environments leading low therapeutic effect and low bioavailability. Mesoporous silica nanoparticles (MSN) are biocompatible biomaterials that have a large surface area, high pore volume, and enhanced adsorption capacity. With MSN-mediated controlled drug release, the active substance concentration is kept within the desired therapeutic range. In this study, it is aimed to enhance the PCZ adsorption and release by using a MSN based drug delivery system. MSNs were synthesized by sol-gel method. Specific surface area and pore diameter of MSN was measured as 705.9 m2/g and 3.33 nm, respectively. Surface modification of nanoparticles was achieved using (3-Aminopropyl) triethoxysilane (APTES). Zeta potential of APTES- modified MSN (MSN-NH2) measured higher compared to zeta potential of MSN. PCZ was loaded on MSN- NH2 with a loading efficiency of 35%. The release profile of PCZ from MSN-NH2was observed as diffusion controlled release, and 19% of PCZ was released at the end of 16 hours. According to the MTT test, drug loaded MSN-NH2 showed cell viability greater than 90%.