Claisen type Condensation of Methyl Ketones with Carbimidothioates: A New Gateway for the Synthesis of beta-Enaminones

Swaroop T. R., Rangappa K. S., TORUN L.

CHEMISTRYSELECT, cilt.6, sa.2, ss.177-180, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/slct.202004295
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.177-180
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Carbimidothioates are synthesized by the reaction of Grignard reagents or heteroaryl lithium compounds with arylisothiocyanates followed by treatment with methyl iodide. Further, application of these intermediates in the synthesis of beta-enaminones by their condensation with methyl ketones in the presence of sodium hydride in DMF is reported. This method offers a new gateway for the synthesis of beta-enaminones, which are important building blocks in synthetic organic chemistry.