Claisen type Condensation of Methyl Ketones with Carbimidothioates: A New Gateway for the Synthesis of beta-Enaminones

Swaroop T. R. , Rangappa K. S. , TORUN L.

CHEMISTRYSELECT, vol.6, no.2, pp.177-180, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1002/slct.202004295
  • Title of Journal : CHEMISTRYSELECT
  • Page Numbers: pp.177-180


Carbimidothioates are synthesized by the reaction of Grignard reagents or heteroaryl lithium compounds with arylisothiocyanates followed by treatment with methyl iodide. Further, application of these intermediates in the synthesis of beta-enaminones by their condensation with methyl ketones in the presence of sodium hydride in DMF is reported. This method offers a new gateway for the synthesis of beta-enaminones, which are important building blocks in synthetic organic chemistry.