Biophysical characterization of quaternary pyridinium functionalized polynorbornenes for DNA complexation and their cellular interactions

GOKCE Z. G., BIROL S. Z., Eren T., CEYLAN S. E.

BIOPOLYMERS, vol.107, no.4, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1002/bip.23005
  • Journal Name: BIOPOLYMERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Yıldız Technical University Affiliated: Yes

Abstract

Cationic polymers with hydrophobic side chains have gained great interest as DNA carriers since they form a compact complex with negatively charged DNA phosphate groups and interact with the cell membrane. Amphiphilic polyoxanorbornenes with different quaternary alkyl pyridinium side chains with ethyl- p(OPy2) and hexyl unitsp(OPy6) bearing 10 kDa MWT were synthesized by living Ring- Opening Metathesis Polymerization method.