Engineered Peptide Repairs Defective Adhesive-Dentin Interface

Ye Q., Spencer P., Yuca E., Tamerler C.

MACROMOLECULAR MATERIALS AND ENGINEERING, cilt.302, sa.5, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 302 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/mame.201600487
  • Dergi Adı: MACROMOLECULAR MATERIALS AND ENGINEERING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: adhesive, dentin interface, composite restorative materials, material-tissue interface, mineralization, peptides, RESIN-BASED COMPOSITE, IN-VITRO PERFORMANCE, AMALGAM, HYDROXYAPATITE, RESTORATIONS, REMINERALIZATION, SURVIVAL
  • Yıldız Teknik Üniversitesi Adresli: Evet

Özet

Failure of dental composite restorations is primarily due to recurrent decay at the tooth-composite interface. At this interface, the adhesive and its bond with dentin is the barrier between the restored tooth and the oral environment. In vivo degradation of the bond formed at the adhesive/dentin (a/d) interface follows a cascade of events leading to weakening of the composite restoration. Here, a peptide-based approach is developed to mineralize deficient dentin matrices at the a/d interface. Peptides that have an inherent capacity to self-assemble on dentin and to induce calcium-phosphate remineralization are anchored at the interface. Distribution of adhesive, collagen, and mineral is analyzed using micro-Raman spectroscopy and fluorescence microscopy. The analysis demonstrates remineralization of the deficient dentin matrices achieved throughout the interface with homogeneous distribution of mineral. The peptide-based remineralization demonstrated here can be an enabling technology to design integrated biomaterial-tissue interfaces.