Akademik Veri Yönetim Sistemi
Inorganic Biomaterials for Drug Delivery, Elsevier, ss.221-260, 2025
Hydroxyapatite (HAp) is a calcium phosphate material that belongs to the biomaterial class. It exhibits a high degree of chemical similarity to the mineral phase found in bone tissue, facilitating bone formation. Thanks to its biological activity, surface properties that allow modification, and a controllable porous structure, it has attracted attention as a carrier material in drug delivery systems (DDSs) in recent years. The role of biocompatible and biodegradable HAp in the transport of proteins, peptides, genetic material, and therapeutic agents is increasing. Control over drug loading and release properties can be achieved by synthesizing HAp particles with various sizes and morphologies. For HAp to be preferred in DDSs, subjects such as targeted response conditions, the need for targeting drug carriers to a certain region, and the control of drug release rate still need to be investigated, and the interest in this subject continues to increase. This study offers a review of recent research highlighting the benefits of employing HAp bioceramic particles in DDSs.