Akademik Veri Yönetim Sistemi
7th European Symposium of Photopolymer Science, İstanbul, Türkiye, 19 Eylül - 22 Ekim 2022, ss.74
Due to their unique properties gold nanoparticles (AuNps) are among the most widely used inorganic nanoparticles for the development of innovative therapeutic approaches due to their unique properties [1]. Apart from AuNps, platinum nanoparticles (PtNps) find a wide range of uses, from biomedical devices to nanomedicine, due to their intrinsic catalytic
and absorption properties. However, clinical studies of PtNps are limited due to various toxicological concerns [2].
Thioxanthone derivatives are well known type II photoinitiators [3]. In addition to UV curing applications, studies in which various thioxantone derivatives are used as photoreducing molecules are carried out by Arsu and co-workers [4]. In addition, thioxanthones have been shown to exhibit anticancer activities, leading to the development of new pharmaceuticals [5].
In this study, Au@Pt bimetallic nanoparticles (Au@PtNp) suitable for photothermal therapy were successfully synthesized using the photochemical reduction method, which is environmentally friendly, practical, and fast in order to use the advantages of two different nanoparticles and minimize their disadvantages.
[NH₂-TX-S-]₂ molecule, which is a thioxanthone disulfide derivative, was used as a photoreducing agent for this process. Doxorubicin, a model cancer drug, was loaded onto the synthesized nanoparticles and it was aimed to use the nanoparticles as drug carriers at the same time. The drug release properties of drug-loaded Au@PtNp were investigated at
different pHs in the dark and near IR light irradiation.
Lastly, the synergistic effect of both photothermal and chemotherapy treatments using Au@PtNp was determined by MTT experiments on healthy and cancer cells.
This work was supported by Yildiz Technical University research fund for MSc Project. Project ID: FYL-2021-4420.